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Anti-APP Antibody (CAT#: MOM-18229)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human APP Antibody MOM-18229 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Human Antibody is against Human Abeta, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • Abeta
  • Type
  • Human IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • Specific Activity
  • Tested positive against native antigen.
  • Protein Construction
  • Immunoglobulin G1, anti-(human beta-amyloid peptides A beta42 and A beta40) human monoclonal antibody; gamma1 heavy chain (Homo sapiens VH-IGHG1) (229-215')-disulfide with kappa light chain (Homo sapiens V-KAPPA-IGKC); (235-235":238-238")-bisdisulfide dim
  • Predicted N terminal
  • H chain: QVELVES; L Chain: DIVLTQS
  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Antigen Description
  • Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
  • Function
  • DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;
  • Synonyms
  • APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;

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